Drug Profile Drugs And Drugs - 1406 Words

Level 1: Drug Profile Coursework Drug substance: Pioglitazone Name: Cheong Hung Shing Student number: 40168923 Assessor: Dr P. McCague ï  ¬ 1.1 Source Pioglitazone is one kind of thiazolidinediones which is a type of anti-diabetic drugs. It is a synthetic substance. It has brand names of Actos ®. [1][2] ï  ¬ 1.2 Description Pioglitazone is 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione. It has a chemical formula of C19H20N2O3S and a molecular weight of 356.4387 g/mol. [3] It exists as white or almost white crystal or crystalline powder [4] which has a melting point between 183â„Æ' - 184â„Æ'. [5] It has the following structure: Figure 1: Structure of Pioglitazone molecule 98.0% - 102.0% purity is required for use as a drug substance. [4] ï  ¬ 1.3 Solubility Pioglitazone is insoluble in water but slightly soluble in methanol and very slightly soluble in methylene chloride. [4] ï  ¬ 2.1 Medical use and physiology effect Pioglitazone is used for controlling high blood pressure with type 2 diabetes along with a proper diet and exercise program. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes can also prevent the risk of getting a heart attack or stroke. [6] The level of sugar in blood is controlled by insulin which is naturally made by in human body by the pancreas. When the amount of insulin is insufficient or insulin is not workingShow MoreRelatedDrug Profile1262 Words   |  6 PagesDrug Profile Drug Profile * * Addiction is an escape of experiencing control it is an illusion and a mood altering experience. A pathological relationship with life-threatening or negative consequences, it is the experience that is addicting. People can become addicted to anything that alters our mood or consciousness. Addiction can be about self-harm and when done repeatedly it will stop or ease emotional pain that a person may be going through. An individual’s addiction can showRead MoreDrug Profile Paper1105 Words   |  5 PagesDrug Profile Paper University of Phoenix PSY/425 March 22th, 2012 Drug Profile Paper This paper will illustrate several aspects of how drugs affect our lives. Addiction philosophies including the psychology and physiology will be explained in an attempt to describe how drugs affect our bodies both physically and mentally. Secondly, different drug categories types will be covered including: stimulants, depressants, narcotics, hallucinogens, and cannabis. Each of these categories has differentRead MoreDrug Profile : Drugs And Treatment And Prevention Of Venous Thromboembolism1121 Words   |  5 PagesWarfarin Drug profile Generic name: Warfarin Trade names: Coumadin, Jantoven Drug class: vitamin K antagonist (Medicinenet.com, 2013) Formulations: Tablets: 1, 2, 2.5, 3, 4, 5, 6, 5, 7.5 and 10 mg. Powder for Injection: 5 mg/vial (Medicinenet.com, 2013) Indications: Warfarin is primarily used for treatment and prevention of venous thromboembolism, and to reduce risk of pulmonary embolism. Warfarin may also be used to prevent strokes in patients with atrial fibrillation or artificial heart valvesRead MoreGeneric Drug Profile : Salbutamol1288 Words   |  6 PagesGeneric Drug Profile - Salbutamol New Zealand trade names: Ventolin, Respigen, Salamol, Asthalin, Salapin and Broncolin. Drug Class: Therapeutic class: bronchodilator. Pharmacologic class: sympathomimetic (stimulates the sympathetic nervous system). It is also classified as a SABA (short acting ÃŽ ²2-agonist). Formulations: The most common administration is by inhalation of a pressurised metered dose aerosol. Inhalation of Salbutamol directly reaches the lungs and acts rapidly with fewer side effectsRead MoreImplementation Analysis : Cell Morphological Enrichment Analysis1665 Words   |  7 Pagestranscriptomic profile} We applied the least absolute shrinkage and selection operator (LASSO) to test our main assumption that gene expression changes in response to perturbations can be used to identify associated changes in cell morphological features. The prediction error of the LASSO model was measured by cross validation (LOOCV). In each LOOCV iteration, we first mapped the transcriptomic response profile of an indicated drug against the reference repository to identify similar profiles. Next, weRead MoreThe War On Drugs And The United States1506 Words   |  7 Pages When, in 1971, Richard Nixon infamously declared a â€Å"war on drugs† it would have been nearly impossible for him to predict the collective sense of disapprobation which would come to accompany the now ubiquitous term. It would have been difficult for him to predict that the drug war would become a hot topic, a highly contentious and polarizing point of debate and, it would have difficult for him to predict that the United States would eventually become the prison capital of the world, incarceratingRead MoreA Diverse And Sustainable Compound Library For Aid Drug Development And Sales1185 Words   |  5 PagesA diverse and sustainable compound library to aid drug development and sales. ________________________________________ Public Profile The consumer-facing side of your profile is written so anybody can easily understand your product or service. Information about the investment opportunity is detailed on the â€Å"Business Plan† side of the profile to maintain compliance with SEC ‘general solicitation’ regulation. Carmolex Inc. 3-5 sentence â€Å"quick pitch† outlining key takeaways that will be exploredRead MoreInternational Drug Monitoring For The Thalidomide Disaster Detected1301 Words   |  6 Pagesas Drug Safety, is defined as the science and activities relating to the detection, collection, assessment, monitoring, understanding and prevention of adverse effects (AEs) or any other drug-related problem. World health organization (WHO) established its programme for International Drug Monitoring in response to the thalidomide disaster detected in 1961. The aims of PV are to enhance patient care and patient safety in relation to the use of medicines; and to ensure the risk-benefit profile of medicinesRead MoreTranscriptomic And Cell Morphological Profiles886 Words   |  4 Pagesthis step, we use LINCS online resources to provide transcriptomic and cell morphological profiles of drugs and small compound molecules as a back-end data for our proposed pipeline. Step II: Mapping the query transcriptomic profile against the LINCS repository. We compare the query signature of expressions for Landmark Genes measured by L1000 assay and the reference transcriptomic profiles to find the drugs and small compound molecules that can potentially mimic the gene expression pattern of theRead MoreEssay On Cell Morphological Features933 Words   |  4 Pagesrelated transcriptomic profiles to predict cell morphological states for a transcriptomic profile of interest (Figure 1, Step IVa) \cite{11}. We hypothesize similar transcriptomic profiles that mimic a query gene expression pattern can be applied using appropriate computational model to predict changes in cell morphological features in response to a compound treatment \cite{13}. We use LASSO to fit a regression model for changes in cell morphology and gene expression profiles in response to treatment